繼續教育課程

酒精不耐症及台灣的飲酒問題

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本課程為台灣急診醫學會2020年學術討論會之錄製內容,不可取得學分

課程簡介

Symposium I:酒精不耐症及台灣的飲酒問題-從精準急診醫學到公衛教育的探討

Alcohol Intolerance and Alcohol Burden in Taiwan: From Precision Emergency Care to Public Health Education

講座內容

從精準急診醫學到公衛教育的探討

  (陳哲宏資深硏究員,美國史丹佛大學醫學院)

簡介

台灣有將近一半的民眾帶有ALDH2基因突變所導致的酒精不耐症,盛行率居世界第一。此類民眾一喝酒就臉紅,因為缺乏乙醛去氫酶,無法正常代謝酒精產生的乙醛。酒類飲品及飲酒所產生的乙醛是一級致癌物。乙醛除了引起臉紅以外還會導致心跳加快、頭痛、頭暈、嘔吐、宿醉等症狀。台灣843萬成人飲酒人口中有100萬人有暴飲情形。台灣因不當飲酒導致每年約4,500人死亡,其中29% 死於酒駕、意外事故及暴力傷害。酒精不耐症更是口腔、食道、大腸直腸癌等疾病的高風險因子。不當飲酒造成台灣每年35億元醫療資源負擔及549億元經濟損失。如何應用ALDH2基因檢測於急症室中對飲酒問題的處治及從對民眾的酒精不耐症教育宣導到合理的酒害公衛預防政策都是值得去探討的重要課題。

Taiwan has the highest prevalent rate of alcohol intolerance in the world due to a common genetic mutation in ALDH2. Carriers with the ALDH2 mutation cannot metabolize alcohol-derived acetaldehyde efficiency and are characterized by facial flushing after alcohol consumption. Alcoholic beverage and acetaldehyde converted from alcohol have been classified as group 1 carcinogens. In addition to alcohol-induced facial flushing, headache, dizziness, vomiting and hangover are other symptoms of alcohol intolerance. In Taiwan, 843 million adult consumption alcohol regularly. Among them, 100 million experienced heavy or binge drinking. More than 4,500 deaths are caused by harmful alcohol drinking annually in Taiwan. 27% of the deaths are due to traffic accidents, injuries and violence. Alcohol intolerance is also a high health risk factor for oral, esophageal, colorectal cancers and other diseases. Harmful alcohol drinking incurs approximately NT$3.5 billion in medical costs and 54.0 billion economic costs in Taiwan per year. The application of ALDH2 genetic test in alcohol-related emergence room situation, the needs for public education on alcohol intolerance, and the legislation and implementation of appropriate alcohol public health policy are therefore urgent issues to be explored in Taiwan.

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